Chronic Lymphocytic Leukaemia: KOL Insight

Chronic Lymphocytic Leukaemia: KOL Insight

Code: FW-20150901 | Published: Sep-2015 | Pages: - | FirstWord
Price :

* Required Fields



In the last few years the emergence of new targeted therapies such as AbbVies/Janssens kinase inhibitor Imbruvica (ibrutinib) and Gileads P13K inhibitor Zydelig (idelalisib) have delivered effective therapies to previously underserved markets. Yet the arrival of AbbVies/Roches venetoclax looks to be a further game changer with its ability to induce complete remissions within a fixed treatment window. What impact will this new therapy have on the competitive landscape? How might it change the treatment paradigm and how do KOLs see it changing clinical practice?

This comprehensive report reveals critical insights from 12 leading North American and European KOLs - see who they are. Find outhow they view the clinical benefits of current and late stage products, potential drug combinations, and the patients condition state and financial concerns that determine therapy choice. See what marketed and pipeline drugs are discussed in the report - click here

Answering key questions

- With biosimilar rituximab on the horizon, can Roche successfully protect Rituxan/MabThera revenues, and if so, how?
- What combinations are seen by KOLs as key to Roches Gazyva/Gazyvaro (obinutuzumab) future competitiveness?
- Is there a place for Novartis Arzerra (ofatumumab) in the treatment paradigm. And if so, where does it fit in?
- While AbbVies/Janssens Imbruvica (ibrutinib) dominates the market for patients with relapsed or refractory CLL, the high cost and indefinite duration of treatment is limiting growth - how can AbbVie/Janssen respond as competition grows?
- What are the prospects for Infinitys/AbbVies duvelisib and Celgenes lenalidomide pipeline therapies?
- Where do KOLs see Roches/AbbVies impressive venetolax (ABT-199) finding a place in the treatment paradigm now and in the future
- How might the treatment algorithm for high-risk CLL patients with the TP35 defect change and which therapies could move into the first-line setting?

Key issues explored

- Critical factors affecting prescribing decisions: Know the detailed opinions of the leading KOLs on current and late stage CLL therapies and what they see as the critical clinical advantages/disadvantages affecting their decision to prescribe
- The significance of genetic risk factors: Appreciate the role genetic risk factors and co-morbidities play in determining treatment choice and identify key areas for strategic and tactical action
- Combination therapies and the treatment paradigm: Understand how combination therapy fits into the treatment paradigm and identify the products that will be positively or adversely affected
- Exclusive KOL opinion into current clinical trials: Review KOL attitudes to recently completed or ongoing clinical trials such as HELIOS, CLL11, COMPLEMENT 1 and RESONATE-2

Key Takeaways

- Formulate effective strategies for product positioning, pricing and clinician messaging
- Map new treatment options to CLL patients and patient sub-groups and identify niche opportunities
- Identify product attributes and patient characteristics that the KOLs think are the most important in terms of prescribing decisions and position in the treatment algorithm
- Appreciate the growing concern with drug prices and the negative effect it is having on uptake
- Discover which clinical trials the KOLs believe will have a significant impact on future treatment decisions and their likely outcomes
- Evaluate the changing and challenging competitive landscape as wider clinical adoption and experience with new products impacts prescribing choice

Features of the report

- Knowledgeable "real-world" opinions of leading US and European KOLs that is not available in any other report
- Detailed and candid views on the future positioning and competitiveness of current and upcoming CLL therapies
- Essential insights that answer critical business questions and provide a platform for strategic planning and tactical engagement.

KOL Panel

KOLs from North America:

- Steve Coutre, MD, Professor Hematologist, Stanford Cancer Center, Stanford, CA, USA.
- Bruce Cheson, MD, FACP, FAAS, Professor of Medicine, Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington DC, USA.
- Steven T. Rosen, MD, provost and chief scientific officer for City of Hope, Duarte, CA, USA.
- Farhad Ravandi, MD, Professor and Chief, Section of Developmental Therapeutics within the Department of Leukemia, Division of Cancer Medicine at MD Anderson, Houston, TX, USA.
- David Spaner, MD, FRCPC, PhD, Associate Professor and Senior Scientist Sunnybrook Health Sciences Centre, Odette Cancer Centre, University of Toronto, Canada.
- Anonymous US KOL, Associate Professor of Haematology in the Division of Medical Haematology at a large US academic medical center.

KOLs from Europe:

- Christopher Fegan Clinical Professor, Institute of Cancer & Genetics, Cardiff University School of Medicine, Cardiff, UK.
- Anonymous German KOL, Associate Professor and deputy chairman at the Department of Internal Medicine (Haematology, Oncology, Rheumatology and Infectious Diseases) at a University in Germany.
- Anonymous German KOL, Assistant professor and consultant at a large university hospital, Germany.
- Paolo Ghia, MD, Associate Professor in Internal Medicine at the UniversitA Vita-Salute San Raffaele; and Deputy Chairman of the Division of Experimental Oncology, San Raffaele Scientific Institute, Italy.
- Fortunato Morabito, Contract professor for the Clinical Pathology Specialization program of the Faculty of Pharmacy, University of Calabria, Italy.
- Marco Montillo, MD, Director of Chronic Lymphoproliferative Disorders Program at the Department of Hematology of Niguarda Cancer Center, Niguarda CA Granda Hospital in Milan, Italy.

Get detailed KOL views on:


- Marketed drugs
- Rituxan/MabThera (rituximab; Roche/Genentech/Biogen)
- Gazyva/Gazyvaro (obinutuzumab; Roche)
- Arzerra (ofatumumab; Novartis)
- Campath/MabCampath (alemtuzumab; Sanofi)
- Pipeline drugs
- ublituximab (TG-1101; TG Therapeutics)


- Marketed drugs
- Imbruvica (ibrutinib; AbbVie/Janssen Biotech)
- Zydelig (idelalisib; Gilead Sciences)
- Pipeline drugs
- venetoclax (ABT-199; Roche/AbbVie)
- duvelisib (IPI-145; Infinity/AbbVie)
- Revlimid (lenalidomide; Celgene)

Report Format

Following are different modes of Licenses.

a. Single User License:
This license allows only one person to use the report. This person can use the report on any computer and may take print outs of the report but must take care of not sharing the report (or any information contained therein) with any other individual or people. Unless you purchase a Site License or a Global Site License, a Single User License must be purchased for every single person that wishes to use the report within the same enterprise.

b. Single Site License:
This license allows unlimited users to use the report within one company location, e.g. a regional office. These users can use the report on any computer and may take print outs of the report but must take care of not sharing the report (or any information contained therein) with any other individual or people.

c. Global Site License:
A Global Site License (or Enterprise wide Site License or Global License) is a license granted to original purchaser, who can share a report with other employees and authorized Users of the same organization.

Quick Help

1. How do you deliver the reports?
The delivery of reports is depends on format & mode of license of report(s). Following are different kinds of formats of report(s) and their delivery options :

a. Electronic Format – Through email from Publisher
Report will be sent to your username email address in PDF, Excel, PowerPoint or any other electronic / softcopy format by publisher.
Delivery Time: 12 to 48 hours [depending on time difference or occurrences of national holidays]

b. Hard Copy or Printed Format or CD-Rom – Through Mail or Courier from Publisher
Report will be sent through mail / courier delivery to your shipping address by publisher.
Delivery Time: Less than, few weeks [depending on time difference or occurrences of national holidays]

2. How can I make payment for publications I purchase?
You could be able to make the payment, in following ways:

a. Online Secure Payment through Credit Card Payment : We accept Visa, Master, AMEX Cards & CCAvenue
b. Transfer of fund to our bank account via Bank transfer or Wire transfer
c. Payment via DD or Cheque
d. Paypal

3. Is it safe to use my credit card on MarketinfoResearch?
Your personal information and online tranaction on Marketinfo Research is secure, private, and tamper-proof. All credit card payments are processed through secure and trusted payment gateways.

If you have a more question about our publications please see our FAQs section or contact us now at


There are no reports matching the selection.

Browse similar reports by category:
Pharmaceuticals & Healthcare

Our Clients