Multiple Sclerosis: KOL Insight

Multiple Sclerosis: KOL Insight

Code: FW-20151001 | Published: Oct-2015 | Pages: - | FirstWord
Price :

* Required Fields



Roches/Biogens novel ocrelizumab is set to radically alter the Multiple Sclerosis (MS) treatment paradigm. Which companies and products will lose market share as its use widens and what clinical benefits underpin KOL excitement? Could it challenge interferon therapy? Where will oral therapies such as Novartis Gilenya (fingolimond) fit in? Where will Biogens well regarded Tecfidera (dimethyl fumarate) find a role?

This report reveals the unique insights of 12 leading US and European KOLs - see who they are. How they view the clinical benefits of current and late-stage disease-modifying agents, safety concerns and the influence patients exert are fully explored. The report analyses 8 leading launched products and 8 significant late-stage therapies see full list.

View: US KOLS, EU KOLS, Market drugs, Pipeline drugs

"Ocrelizumab is the most exciting of all the MS drugs. This drug will take markets. This will be the most disruptive therapy of any therapy weve discussed." EU KOLv

Answering key questions

- Ocrelizuzimab: What safety and dosage benefits underpin KOLs positive opinions about ocrelizumab?
- Copaxone/Glatopa: Will longer acting formulations help Teva defend Copaxone revenues against Sandoz/Momentas Glatopa (generic glatiramer acetate)?
- Gilenya/Tecfidera: Have safety concerns blunted the growth of NovartisGilenya (fingolimond) and Biogens Tecfidera (dimethyl fumarate) - how do KOLs see their role in the treatment paradigm evolving?
- Plegridy: How is the launch of Plegridy impacting other interferon products and what effect will this have on the interferon market as a whole?
- Lemtrada: How might the CAM-THY, EMERALD and TOPAZ trials for Sanofis/Genzymes Lemtrada (alemtuzumab) influence KOLs views?
- Ozanimod/siponimod: Can new sphingosine modulators such as Celgenes ozanimod, Novartis siponimod and Actelions ponesimod differentiate themselves against established therapies and find a market?
- Biotin: MedDays ultra-high dose biotin (MD 1003) is showing promise for progressive diease and could be an effective low-cost treatment - but what KOL concerns do MedDay have to address in clinical trials?

Top Takeaways

- A changing treatment paradigm: While ocrelizumab will initially compete as a second line in RRMS it could move to first line therapy and get traction in PPMS. Understand its clinical benefits and why it is being seen as a really potent alternative to current products.
- A question of safety: Many treatments are effective in treating MS but come with a range of adverse reactions. Assess the impact safety is having on prescribing habits and how new therapies will benefit.
- Patient preferences: Appreciate how patient choice plays a key role in prescribing decisions. The route of administration and frequency of treatment are critical to patient buy-in and healthcare cost control.
- The next generation: Understand why Anti-LINGO could be the next game changer in multiple sclerosis.
- Underserved patient populations: While there are plenty of options for the treatment of RRMS , there remains an unmet need for progressive forms of the disease - how will new treatments play a role?
- Combination Therapy: Most MS treatments are given as monotherapy, and cost is cited as the dampener of combination treatment. Could innovative pricing be an opportunity area and would the clinical benefits justify the increase?
- Research points the way: Review KOL attitudes to recently completed or ongoing clinical trials such as BEST-MS, CAM-THY, ORATORIO, OPTIMUM, ARPEGGIO and EXPAND.

Key Issues Explored

- Patients play a critical role in therapy choice. The frequency of treatment, additional monitoring and fear of adverse reactions are just some of the issues that clinicians take into account. Its more than just efficacy and there are lessons for companies for their patient outreach programmes.
- There is much promise in the new therapies coming to market but they are competing with established products whose profile and risks are known - it will take some time to build clinical confidence and start to fully realise their potential - medical and patient education will play a key role.
- Product differentiation is critical in getting formulary placement. Knowing what product attributes and patient characteristics KOLs think are the most important in terms of prescribing decisions are "must-know" to ensure commercial success.
- Unlike many treatment areas, combination therapy is not common in MS. KOLs cite cost as an issue, but could progressive pricing and combination therapy be considered as an end game for products superseded by new therapies?
- How do KOLs view high-dose biotin (MD 1003) and what specific advantages would such a product have?

A report based on expert knowledge


- Dr Robert Naismith, MD, Associate Professor of Neurology and Neurology Clerkship Director at Washington University in St. Louis
- Dr Benjamin M. Greenberg, MD, Associate Professor and the Cain Denius Scholar in Mobility Disorders in the Department of Neurology and Neurotherapeutics at UT Southwestern Medical Center
- Dr Daniel Harrison, MD, Assistant Professor of Neurology at Johns Hopkins University Medical Center and a faculty member of the Johns Hopkins MS Center
- Dr Shiv Saidha, M.B.B.Ch, Assistant Professor of Neurology at Johns Hopkins University School of Medicine
- Dr Darin T. Okuda, MD, Director of the Multiple Sclerosis and Neuroimmunology Imaging Program and the Deputy Director of the MS Program and Clinical Center for Multiple Sclerosis at the University of Texas Southwestern Medical Center in Dallas, Texas
- Dr Anne Cross, MD, Professor of Neurology and Section Head of Neuroimmunology at Washington University School of Medicine, St. Louis


- Prof Cris Constantinescu, Head of the Academic Division of Clinical Neurology at the University of Nottingham; senior consultant in charge of the MS Clinic, University Hospital Nottingham
- Prof Nighoghossian, Chief Neurologist at CHU Lyon, France
- clinic in a university hospital.
- Dr Elio Scarpini, Chief of the Center for Neurodegenerative and Demyelinating Disorders, University of Milan, Fondazione IRCCS CA Granda, Ospedale Policlinico, Milan, Italy
- Dr Belen Caminero, is responsible for the Multiple Sclerosis Unit in the Healthcare Complex of Avila, Spain.
- Anonymous, German KOL, is a Professor of Neurology. This expert is Managing Lead Consultant of a neurology
- Anonymous, European KOL, Principal investigator on several multinational MS clinical trials

Get KOL insights on

Marketed MS Drugs

- Interferons (Avonex, Rebif, Betaseron, Extavia)
- Plegridy (peginterferon beta-1a/BIIB017; Biogen)
- Copaxone (glatiramer acetate; Teva)
- Tecfidera (dimethyl fumarate; Biogen)
- Aubagio (teriflunomide; Sanofi/Genzyme)
- Gilenya (fingolimod; Novartis/Mitsubishi Tanabe Pharma)
- Tysabri (natalizumab; Biogen)
- Lemtrada (alemtuzumab; Sanofi/Genzyme/Bayer HealthCare)

MS Pipeline

- Zinbryta (daclizumab high-yield process, DAC-HYP; Biogen/AbbVie)
- Nerventra (laquinimod; Active Biotech/Teva)
- Ozanimod (RPC 1063; Celgene)
- Siponimod (BAF 312; Novartis)
- Ponesimod (ACT 128800; Actelion)
- Ocrelizumab (Roche/Biogen)
- Masitinib (AB 1010; AB Science)
- Biotin (MD 1003; MedDay)

Ongoing Benefits

The world of pharma is ever changing and executives must always be up-to-date with new developments that could affect their own products, position and research. That is why FirstWords guarantee to keep Therapy Trends clients up to date with Update Bulletins offers a real commercial advantage.

Update Bulletins include expert insight and analysis based on FirstWord analyst re-engagement with the KOLs after major events such as product approvals, key data releases and major conferences to deliver the most valuable insights with each update.

Your Therapy Trends Report purchase entitles you to receive three Update Bulletins, which are published approximately every three months for 12 months following the reports publication date, October.
You will receive a copy of each Update Bulletin once available, which are issued each quarter after the publication date.

Report Format

Following are different modes of Licenses.

a. Single User License:
This license allows only one person to use the report. This person can use the report on any computer and may take print outs of the report but must take care of not sharing the report (or any information contained therein) with any other individual or people. Unless you purchase a Site License or a Global Site License, a Single User License must be purchased for every single person that wishes to use the report within the same enterprise.

b. Single Site License:
This license allows unlimited users to use the report within one company location, e.g. a regional office. These users can use the report on any computer and may take print outs of the report but must take care of not sharing the report (or any information contained therein) with any other individual or people.

c. Global Site License:
A Global Site License (or Enterprise wide Site License or Global License) is a license granted to original purchaser, who can share a report with other employees and authorized Users of the same organization.

Quick Help

1. How do you deliver the reports?
The delivery of reports is depends on format & mode of license of report(s). Following are different kinds of formats of report(s) and their delivery options :

a. Electronic Format – Through email from Publisher
Report will be sent to your username email address in PDF, Excel, PowerPoint or any other electronic / softcopy format by publisher.
Delivery Time: 12 to 48 hours [depending on time difference or occurrences of national holidays]

b. Hard Copy or Printed Format or CD-Rom – Through Mail or Courier from Publisher
Report will be sent through mail / courier delivery to your shipping address by publisher.
Delivery Time: Less than, few weeks [depending on time difference or occurrences of national holidays]

2. How can I make payment for publications I purchase?
You could be able to make the payment, in following ways:

a. Online Secure Payment through Credit Card Payment : We accept Visa, Master, AMEX Cards & CCAvenue
b. Transfer of fund to our bank account via Bank transfer or Wire transfer
c. Payment via DD or Cheque
d. Paypal

3. Is it safe to use my credit card on MarketinfoResearch?
Your personal information and online tranaction on Marketinfo Research is secure, private, and tamper-proof. All credit card payments are processed through secure and trusted payment gateways.

If you have a more question about our publications please see our FAQs section or contact us now at cs@marketinforesearch.com.


There are no reports matching the selection.

Browse similar reports by category:
Pharmaceuticals & Healthcare

Our Clients