Physician Views: Assessing new competitive trends in the oral anticoagulant market

Physician Views: Assessing new competitive trends in the oral anticoagulant market

Code: FW-20150607 | Published: Jun-2015 | Pages: - | FirstWord
Price :
$695.00
USD

* Required Fields

$695.00

Details






The new class of oral anticoagulants - comprising the Factor Xa inhibitors Xarelto (Bayer/Johnson & Johnson), Eliquis (Bristol-Myers Squibb) and Savaysa (Daiichi Sankyo) and the thrombin inhibitor Pradaxa (Boehringer Ingelheim) - generated combined global sales of $5.8 billion in 2014.

While these products have gained share from warfarin at a slower rate than many analysts had modelled pre-launch, there is an expectation of continued growth through to the end of the decade and beyond as usage continues to expand, likely helped by the launch of reversal antidote products (Physician Views Poll Results: Can Portolas reversal agent act as a growth catalyst for novel anticoagulants?) and ViewPoints: Boehringer Ingelheim poised to leverage idarucizumab to re-energise Pradaxa). Consensus forecasts indicate that combined sales will have expanded to around $12 billion by 2020.

Sharpening focus on the US market, two key trends will drive commercial dynamics over the next few years: acceleration in share gain for Eliquis (2014 sales increased to $774 million from $146 million the previous year) and entry of Daiichi Sankyos third-to market Factor Xa inhibitor Savaysa.

While Pradaxa was the first of the novel oral anticoagulants to launch, rapid accumulation of additional indications (it has the broadest label) and once-daily dosing have propelled Bayer and Johnson & Johnsons Xarelto into a position of market leadership; whereby more prescriptions are written for the drug each week versus its competitors combined. Eliquis initially failed to meet early launch expectations, heightened by a perception that Bristol-Myers Squibb and Pfizers drug has a superior clinical profile, however, subsequent uptake appears to have been helped by approval in additional indications and an effective promotional campaign.

In a recent note to investors, Bernstein analysts wrote that while Eliquis share gain has come primarily at the expense of Pradaxa, continued expansion has also adversely affected Xarelto, with Bayer management having conceded earlier this year that new patient starts on Eliquis were now higher than its own brand in the US market. While the primary objective remains share gain at the expense of warfarin, should Bristol-Myers Squibb and Pfizer choose to launch a secondary front against Xarelto - most likely as share gain from warfarin slows - this could exert pressure on Bayer and Johnson & Johnson.

Another factor to consider is the availability of Savaysa, which has a broadly comparable clinical profile to the other Factor Xa inhibitors. Given both the size of the oral anticoagulant market and anticipated growth rates over the next five to ten years, Daiichi Sankyo could have a sizeable product on its hands. Uptake may be limited by a black box warning which restricts usage of Savaysa to patients with a creatinine clearance lower than 95ml/min; it is estimated that around 20 percent of patients fall outside of the approved guideline. While the boxed warning adversely differentiates Savaysa versus competitor Factor Xa inhibitors, it may act as the catalyst for a more aggressive pricing strategy, suggests Bernstein analyst Ronny Gal.








With these factors in mind, FirstWord is polling US-based cardiologists and primary care practitioners with the following questions


- Eliquis (apixaban) looks to have gained notable market share over the past year. What factor do you think has primarily driven this?
- Versus competitor products, how would you expect your usage of Eliquis to evolve over the next five years?
- A fourth novel anticoagulant - Savaysa (edoxaban) - has entered the US market this year. What is your assessment of Savaysas competitive profile?
- Would aggressive discounting for Savaysa compensate for its black box warning and drive an increase in your usage of the product?
- Based on its other clinical credentials, such as once-daily dosing, if post marketing analysis supported removal of the black box warning would you expect your usage of Savaysa to increase over the next five years?



Report Format

Following are different modes of Licenses.

a. Single User License:
This license allows only one person to use the report. This person can use the report on any computer and may take print outs of the report but must take care of not sharing the report (or any information contained therein) with any other individual or people. Unless you purchase a Site License or a Global Site License, a Single User License must be purchased for every single person that wishes to use the report within the same enterprise.

b. Single Site License:
This license allows unlimited users to use the report within one company location, e.g. a regional office. These users can use the report on any computer and may take print outs of the report but must take care of not sharing the report (or any information contained therein) with any other individual or people.

c. Global Site License:
A Global Site License (or Enterprise wide Site License or Global License) is a license granted to original purchaser, who can share a report with other employees and authorized Users of the same organization.

Quick Help

1. How do you deliver the reports?
The delivery of reports is depends on format & mode of license of report(s). Following are different kinds of formats of report(s) and their delivery options :

a. Electronic Format – Through email from Publisher
Report will be sent to your username email address in PDF, Excel, PowerPoint or any other electronic / softcopy format by publisher.
Delivery Time: 12 to 48 hours [depending on time difference or occurrences of national holidays]

b. Hard Copy or Printed Format or CD-Rom – Through Mail or Courier from Publisher
Report will be sent through mail / courier delivery to your shipping address by publisher.
Delivery Time: Less than, few weeks [depending on time difference or occurrences of national holidays]


2. How can I make payment for publications I purchase?
You could be able to make the payment, in following ways:

a. Online Secure Payment through Credit Card Payment : We accept Visa, Master, AMEX Cards & CCAvenue
b. Transfer of fund to our bank account via Bank transfer or Wire transfer
c. Payment via DD or Cheque
d. Paypal


3. Is it safe to use my credit card on MarketinfoResearch?
Your personal information and online tranaction on Marketinfo Research is secure, private, and tamper-proof. All credit card payments are processed through secure and trusted payment gateways.

If you have a more question about our publications please see our FAQs section or contact us now at cs@marketinforesearch.com.

CUSTOMERS WHO VIEWED THIS REPORT ALSO VIEWED

There are no reports matching the selection.

Browse similar reports by category:
Pharmaceuticals & Healthcare
FirstWord

Our Clients